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B P Imbimbo Selected Research

1- (3',4'- dichloro- 2- fluoro(1,1'- biphenyl)- 4- yl)cyclopropanecarboxylic acid

8/2015CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid.
4/2014CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice.
3/2014Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.
3/2009CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease.

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B P Imbimbo Research Topics

Disease

6Alzheimer Disease (Alzheimer's Disease)
04/2014 - 01/2000
3Cognitive Dysfunction
08/2015 - 08/2011
2Vomiting
01/2001 - 01/2000
2Nausea
01/2001 - 01/2000
2Bradycardia
11/2000 - 10/2000
1Hyperalgesia
11/2020
1Ulcer
11/2020
1Skin Ulcer
11/2020
1Pressure Ulcer (Bedsore)
11/2020
1Wounds and Injuries (Trauma)
11/2020
1Encephalitis (Encephalitis, Rasmussen)
08/2015
1Amyloid Plaque
04/2014
1Memory Disorders (Memory Loss)
04/2014
1Brain Ischemia (Cerebral Ischemia)
03/2014
1Acidosis
03/2014
1Ischemia
03/2014
1Dementia (Dementias)
08/2011
1Inflammation (Inflammations)
03/2009
1Dizziness (Lightheadedness)
01/2001
1Asthenia
01/2001
1Anorexia
01/2001
1Atrioventricular Block
11/2000
1Sick Sinus Syndrome
11/2000
1Diarrhea
01/2000
1Abdominal Pain (Pain, Abdominal)
01/2000

Drug/Important Bio-Agent (IBA)

41- (3',4'- dichloro- 2- fluoro(1,1'- biphenyl)- 4- yl)cyclopropanecarboxylic acidIBA
08/2015 - 03/2009
3Cholinergic Agents (Cholinergics)IBA
01/2001 - 01/2000
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2011 - 03/2009
2physostigmine heptyl (MF 201)IBA
01/2001 - 01/2000
1Nerve Growth Factor (NGF)IBA
11/2020
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
11/2020
1TOR Serine-Threonine KinasesIBA
11/2020
1Dialysis SolutionsIBA
04/2014
1Glutamic Acid (Glutamate)FDA Link
04/2014
1Fatty Acids (Saturated Fatty Acids)IBA
08/2011
1Monounsaturated Fatty AcidsIBA
08/2011
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
08/2011
1Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA
08/2011
1Amyloid beta-PeptidesIBA
03/2009
1Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2001
1PhysostigmineIBA
01/2001
1Pharmaceutical PreparationsIBA
01/2001
1A 7 (A-7)IBA
01/2001
1AcetylcholinesteraseIBA
01/2001
1Acetylcholine (Acetylcholine Chloride)FDA Link
11/2000
1Muscarinic AntagonistsIBA
11/2000
15- (4- (4- (diethylamino)butyl)- 1- piperidinyl)acetyl- 5H- dibenz(b,f)azepineIBA
10/2000

Therapy/Procedure

1Topical Administration
11/2020
1Mediterranean Diet
08/2011
1Therapeutics
01/2011
1Oral Administration
11/2000